EOLIA Trial
EOLIA Trial
Respiratory Failure Position Paper
Respiratory Failure
Position Paper
IDEA Study
LIFEGARDS Study
Bayesian Analysis of EOLIA
Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review
Bayesian Analyis of EOLIA
CCM Journal Thumbnail
Core Outcome Measures Delphi Study
ETHOS Survey
Anticoagulation
ICM2
Cardiac Failure
Position Paper
SUPERNOVA
CHEST
Research in Extracorporeal
Life Support: A Call to Action
The Lancet
ECCO2R Position paper
Publications

 


2019

Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review

Brodie D, Slutsky AS, Combes A. Extracorporeal Life Support for Adults With Respiratory Failure and Related IndicationsA ReviewJAMA. 2019;322(6):557–568.

 

 

 

 

Core Outcome Measures - Delphi Study

Core Outcome Measures for Research in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation for Acute Respiratory or
Cardiac Failure: An International, Multidisciplinary, Modified Delphi Consensus Study

Hodgson CL, Burrell AJC, Engeler DM, Pellegrino VA, Brodie D, Fan E; On behalf of the International ECMO Network. Core outcome measures for research in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) for acute respiratory failure or cardiac failure: an international, multidisciplinary, modified Delphi consensus study. Crit Care Med 2019;53:98-106.

 

 

 

ETHOS

Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey
Abrams, Darryl, MD; Pham, Tài MD; Burns, Karen E. A. MD; Combes, Alain MD; Curtis, J. Randall MD; Mueller, Thomas MD; Prager, Kenneth M. MD; Serra, Alexis MD; Slutsky, Arthur S. MD; Brodie, Daniel MD; Schmidt, Matthieu MD on behalf of the International ECMO Network (ECMONet). Critical Care Medicine. 2019 July 25: Volume Online First - Issue - p

ETHOS is a prospective, multicenter web-based survey in response to a clinical case vignette. The objectives of the study are to depict practice variation regarding ECMO use, maintenance, withdrawal and determination of futility in severe ARDS in an international cohort of ECMO physicians and identify which physician and hospital-centered factors are related to these practices.

 

 

VA ECMO Review

Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications

Burrell AJC, Bennett V, Serra AL, Pellegrino VA, Romero L, Fan E, Brodie D, Cooper DJ, Kaye DM, Fraser JF, Hodgson CL; International ECMO Network (ECMONet). Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications. J Crit Care. 2019 May 24;53:32-37. [Epub ahead of print]

 

 

LIFEGARDS

Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort

Schmidt M, Pham T, Arcadipane A, Agerstrand C, Ohshimo S, Pellegrino V, Vuylsteke A, Guervilly C, McGuinness S, Pierard S, Breeding J, Stewart C, Ching SSW, Camuso JM, Stephens RS, King B, Herr D, Schultz MJ, Neuville M, Zogheib E, Mira JP, Rozé H, Pierrot M, Tobin A, Hodgson C, Chevret S, Brodie D, Combes A; International ECMO Network (ECMONet), and the LIFEGARDS Study Group. Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort. Am J Respir Crit Care Med. 2019 May 30. [Epub ahead of print]

 

Anticoagulation

Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial

Aubron C, McQuilten Z, Bailey M, Board J, Buhr H, Cartwright B, Dennis M, Hodgson C, Forrest P, McIlroy D, Murphy D, Murray L, Pellegrino V, Pilcher D, Sheldrake J, Tran H, Vallance S, Cooper DJ; endorsed by the International ECMO Network (ECMONet). Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial.  Crit Care Med.  2019 Jul;47(7):e563-e571.

 

 

SUPERNOVA

Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med 2019; online Feb 21. 

 

 

 


2018

EOLIA

ECMO to rescue Lung Injury in severe ARDS

Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. N Engl J Med. 2018 May 24;378(21):1965-1975. 

EOLIA is a multicenter, international, randomized, controlled trial run by the REVA network and endorsed by the International ECMO Network. The study hypothesizes that ECMO, instituted early after the diagnosis of very severe ARDS (P:F < 80), would lower the morbidity and mortality associated with this syndrome.

 

Bayesian Analysis of EOLIA

Goligher EC, Tomlinson G, Hajage D, et al. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial. JAMA. 2018;320(21):2251–2259. doi:10.1001/jama.2018.14276

 

 

 

Cardiac Failure Position Paper

Abrams et al. Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med 2018;epublished February 15th

This position paper represents the expert opinion of an international group of physicians, ECMO specialists and allied health-care workers who have expertise relevant to the mechanical circulatory support used to treat patients with severe cardiac failure. The aim of this paper is to provide clinicians, ECMO center directors and coordinators, hospital administrators, healthcare organizations, and regional, national, and international policy makers a consensus approach to the organization of ECMO programs for cardiac failure and cardiac arrest in adults.

 

 

 

Research in Extracorporeal Life Support: A Call to Action

Daniel Brodie, Jean-Louis Vincent, Laurent J. Brochard, Alain Combes, Niall D. Ferguson, Carol L. Hodgson, John G. Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S. Slutsky, V. Marco Ranieri, Jan Bakker, Michael Broome, Jacques Creteur, Daniel De Backer, Luciano Gattinoi, Roberto Lorusso, Stefano Nava, Laurent Papazian, Peter Rimensberger, Claudio Ronco, Robert Sladen, Thomas Staudinger, Fabio Taccone. Research in Extracorporeal Life Support: A Call to Action. Chest. Volume 153, Issue 4. 2018. Pages 788-791.

 

ECCO2R Position paper

Boyle AJ, Sklar MC, McNamee JJ, et al. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6:874–84.

This position paper represents the expert opinion of an international group of physicians and allied health-care professionals who have expertise relevant to the use of extracorporeal CO2 removal (ECCO2R) in clinical trials and practice. It will provide clinicians, ECCO2R providers, policy makers and clinical researchers with a concise summary of the technology and its use in research and clinical practice. This information informs a summary of recommendations for the use of ECCO2R and areas where there is a requirement for further study.

 

IDEA Study

Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A; International ECMO Network (ECMONet), the REVA Research Network and the IDEA Study Group. Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO. An International Multicenter Retrospective Study. Am J Respir Crit Care Med. 2018 Jan 3. doi: 10.1164/rccm.201708-1761OC. [Epub ahead of print]

This study provides, for the first time, detailed descriptive data on the characteristics, the complication and the outcome of adult’s immunocompromised patients receiving ECMO for ARDS. 

 


2014

Respiratory Failure Position Paper

Combes et al. Position Paper for the Organization of Extracorporeal Membrane Oxygenation Programs for Acute Respiratory Failure in Adult Patients. Am J Respir Crit Care Med 2014;190(5):488-496

The aim of this paper is to provide physicians, ECMO center directors and coordinators, hospital directors, health care organizations, regional, national and international policy makers a description of the optimal approach to organizing ECMO programs for acute respiratory failure in adult patients. Importantly, this will help ensure that ECMO is delivered safely and proficiently, such that future observational and randomized clinical trials assessing this technique may be performed by experienced centers under homogeneous and optimal conditions.